Portugal  PORTUGAL 22/04/2022
#CovidNewsDiCYT

How fast does the COVID-19 virus change?

Researchers quantify, for the first time, the mutations generated in a single infection with SARS-CoV-2

The Instituto Gulbenkian de Ciência (IGC) and the Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) are the first to quantify and to characterize the mutations that can be generated by SARS-CoV-2 when it infects cells. The experimental data provides valuable information to understand how the virus evolves in the human population and for the development of antiviral strategies.

 
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Portugal  PORTUGAL 18/02/2022

Tell me what you eat and I will tell you how your microbiota evolves

New study reveals how gut bacteria adapt and affect health in response to diet

New research reveals that diet can change the evolutionary path of bacteria in the gut, within host-relevant timescales. The study, published in Cell Host & Microbe, demonstrates how quickly Bacteroides thetaiotaomicron (B. theta), a prevalent bacterium in the human gut, acquires adaptive mutations in response to dietary changes. These findings show that acquisition of genetic changes can explain the observed microbiota-mediated negative effects that unbalanced diets have on host health.

 

 
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Portugal  PORTUGAL 10/02/2022

Identified the first patients with new rare disease caused by defects in cell division

Collaborative study between clinicians and researchers unravels mutations in the BUB1 gene responsible for developmental problems

A new study published in Science Advances described the first two patients known to have mutations in both copies of BUB1, a critical gene for cell division. Contrary to previous thoughts, these mutations are compatible with life albeit associated with developmental problems. The identification and clinical/molecular characterization of such mutations could improve the diagnosis of this rare neurodevelopmental disorder and the understanding of syndromes with similar features.

 

 
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Spain  ESPAÑA 04/02/2022

A mathematical model may help explain how blood circulates in the brain

UC3M research analyses the appearance of oscillations in flow networks

Research carried out by the Universidad Carlos III de Madrid (UC3M) may help us better understand oscillations in blood flow that occur in the cerebrovascular network, thanks to a theoretical model that allows the flow and accumulation of fluid (in this case, blood) to be taken into account.

 
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Spain  MADRID 28/01/2022

Promotion of the reuse of scientific health data has been investigated

The UC3M is participating in the European FAIR4Health project

Facilitating and promoting that scientific health data is guided by the FAIR principles (Findable, Accessible, Interoperable, Reusable). This is the objective of FAIR4Health, the European scientific project in which researchers from the UC3M have participated, with the aim of demonstrating the potential impact that such a strategy may have on improving various scientific results.

 
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Spain  MADRID 22/12/2021

An aptasensor has been designed to detect the SARS-CoV-2 virus in saliva

This sensor is more sensitive that antigen-based sensors and detects the virus more quickly and cheaply than PCR tests

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.

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Portugal  PORTUGAL 21/12/2021

Unfolding the blindness proteins through fly eyes

IGC and ITQB NOVA researchers identify a new production mechanism for a critical protein for vision in Drosophila fruit flies

Every 6 minutes someone is told they’re going blind. One of the major causes of human blindness is a disease called Retinitis Pigmentosa (RP), which causes progressive degeneration of the retina and vision loss. Approximately one-tenth of Retinitis Pigmentosa cases worldwide are caused by mutations in the rhodopsin gene. Researchers from ITQB NOVA and Instituto Gulbenkian de Ciência had now identified a crucial mechanism for the production of Rhodopsin, the light-sensitive protein of photoreceptors, using fruit flies (Drosophila melanogaster) and human cells as models.

 

 
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Portugal  PORTUGAL 07/07/2021

Into the complexity of microbial communities

New research bridges colonization processes and complexity in interacting systems of microbes, adding to a body of work with implications for understanding how biodiversity is maintained and how it changes

Microbial communities form complex ecosystems, built on networks of interactions. Gut bacteria, inside our bodies are an example, and we depend on them to help us digest food, to control our mood, or to protect us from infection. Nasopharyngeal multi-strain bacteria like Streptococcus pneumoniae are another example, often carried asymptomatically but sometimes causing trouble to the host. Depending on underlying diversity, microbial community dynamics can lead to different outcomes between health and disease, and display different stability or resistance to invasion.

 
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Spain  MADRID 16/06/2021

Mathematics to improve macular degeneration treatment

Age-related macular degeneration is one of the main causes of blindness

Researchers from the Universidad Carlos III de Madrid (UC3M) have created a mathematical model and simulated numerically the progression of age-related macular degeneration, one of the main causes of blindness. This model can be used to better understand how this disease appears and assess the most effective treatments.

 
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Spain  VALLADOLID 03/03/2021

Hydrogel injection may change the way the heart muscle heals after a heart attack

The regeneration of cardiac tissue is minimal so that the damage caused cannot be repaired by itself

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at National University of Ireland Galway, and BIOFORGE Lab, at the University of Valladolid in Spain, have developed an injectable hydrogel that could help repair and prevent further damage to the heart muscle after a heart attack.

 

 
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Portugal  PORTUGAL 10/02/2021

Sepsis: new evidence to understand and fight the disease

Study published in the journal Cell Host & Microbe reveals new mechanisms that confer resistance against sepsis and sheds light on key aspects of hominid evolution

Researchers discover that the loss of a specific molecule may explain how primates evolved to be able to resist to bacterial infections leading to sepsis. The study published in the prestigious scientific journal Cell Host & Microbe reveals that, in mice, the absence of this molecule (the α-Gal glycan) from the antibodies structure increases the ability to the same antibody to kill bacteria. This evolutionary advantage emerged with a cost, the reproductive decline. These findings shed light on key aspects of hominid evolution and reveal new mechanisms that confer resistance against sepsis, crucial to understand and fight the disease.

 
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Spain  MADRID 18/01/2021

A mathematical study describes how metastasis starts

Research by the UC3M and UCM

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression. The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression.

 
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Portugal  PORTUGAL 17/12/2020

A matter of balance: asymmetric divisions are crucial to form a functional retina

Study published in the scientific journal 'eLife' opens new paths for understanding how the complex brain develops its architecture and function

Researchers at the Instituto Gulbenkian de Ciência and the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, have discovered that in the developing retina, and important part of the central nervous system, the divisions leading to the first differentiating neurons are asymmetric and that this asymmetry is necessary to generate the correct types of neurons in the right numbers and proportions. The study, published in the scientific journal eLife, is the first to report this asymmetry and the molecular processes underlying it, opening new paths for understanding how the complex brain develops its architecture and function.

 
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Brazil  BRASIL 20/10/2020

Immunity induced by other coronaviruses may not protect older people against COVID-19

Study led by researchers at Oxford University suggests that after successive infections by the coronaviruses that cause common colds throughout life the defense system becomes specialized and cannot recognize emergent varieties such as SARS-CoV-2

An international research group led by scientists at the University of Oxford in the United Kingdom have developed a mathematical model that may explain why children are less susceptible to COVID-19 while older people frequently become critically ill when infected by the novel coronavirus.

 
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Portugal  PORTUGAL 15/10/2020

New tricks for old antibiotics

Researchers uncovered that a group of antibiotics confers protection against sepsis, beyond their ability to directly control the infection

The study led by Luís Ferreira Moita, principal investigator at Instituto Gulbenkian de Ciência, and published in the journal Immunity, reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection. This finding opens new doors in the field of disease tolerance and positions this group of antibiotics as potential adjuvant treatment for sepsis, due to their effects that go beyond the control of bacterial burden.

 
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Brazil  BRASIL 03/08/2020
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Adipose tissue may be a reservoir for SARS-CoV-2, Brazilian researchers suggest

A study showed that the novel coronavirus can infect human adipocytes and that the viral load is three times higher in aged adipose cells

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.

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Portugal  AVEIRO 03/07/2020

Smell can play an important role in Autism

Published this month in Neuroscience & Biobehavioral Reviews, the work highlights the potential of olfaction as a facilitator and privileged entry point for socio-emotional information in the population with ASD

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.

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Portugal  PORTUGAL 24/06/2020

Hormone involved in obesity is a risk factor for sepsis

A group of scientists from Instituto Gulbenkian de Ciência (IGC) discovered that a hormone that has been pointed out as a treatment for obesity is a risk factor for sepsis

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.Lorem ipsum dolor sit amet, consectetuer adipiscing elit. In eu dui non est venenatis lobortis. Donec iaculis iaculis turpis. In hac habitasse platea dictumst. Aliquam vitae arcu. Maecenas justo tortor, eleifend sed, fermentum vitae, condimentum vitae, diam. Vivamus mattis, ligula vitae commodo vulputate, lorem tellus semper nulla, vitae cursus nunc eros ut massa. Curabitur velit pede, lobortis a, ultrices sit amet, suscipit non, erat.

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Spain  MADRID 01/06/2020
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A geospatial analysis identifies the areas most vulnerable to COVID-19

A report identifies the areas in Spain that require increased measures of protection against new outbreaks of the COVID19 epidemics

A report based on a geospatial analysis conducted by researchers from the Universidad Carlos III de Madrid (UC3M) in collaboration with TAPTAP Digital, using additional data from Predicio and Tamoco, identifies the areas in Spain that require increased measures of protection against new outbreaks of the COVID19 epidemics.

 
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Spain  MADRID 29/05/2020

Research into new treatments for rare genetic diseases

Collaboration between UC3M, Almirall and Fundación MEDINA

The University Carlos III Madrid (UC3M), Almirall, S.A. (ALM) and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations. The project is partially-funded by the Spanish Ministry of Science and Innovation’s Center for Industrial and Technological Development (CDTI).

 
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