Tec de Monterrey researcher proposes pure proteins for better drugs

TEC MONTERREY/DICYT Enhancing drugs' effects in the body by decreasing their quick exit from the bloodstream is the research topic addressed by José González-Valdez, a Tecnológico de Monterrey Ph.D. graduate in Engineering Sciences with an emphasis in Biotechnology, in his thesis "Analysis, Recovery, and Potential New Uses of PEGylated Proteins", aimed at jump-starting the development of new technologies for a more efficient molecular structure of the proteins contained in drugs.

"What we're doing is seeking new strategies or technologies to separate chemically-modified proteins for their potential marketing. In this case, achieving maximum protein purification for regulatory agencies' approval. We don't develop the proteins or the drugs themselves, but rather the different processes to obtain their purification," Dr. González-Valdez explained.

The purification process is done by working with model proteins on which different supports are applied, tests are conducted, and their performance assessed. The structure is thus modified until optimum conditions are found for its separation and the addition of the molecular structure that enhances its characteristics and makes it more resistant.

In his research, Dr. González-Valdez basically follows the protein separation line by several methods, like the development of new chromatographic supports to separate and purify high-value proteins. -